One-Pot Reductive Amination of Carbonyl Compounds Using Sodium Borohydride–Amberlyst 15

Abstract

A fast, efficient, and high-yielding method for the preparation of amines by reductive amination of aldehydes and ketones using sodium borohydride in the presence of Amberlyst 15 in tetrahydrofuran and under solvent-free conditions at room temperature is described.

Keywords:

• Amines
• carbonyl compounds
• reductive amination
• sodium borohydride

ACKNOWLEDGMENT

Financial support of this work from the Research Council of Mazandaran University is gratefully acknowledged.

Notes

^a All reactions were carried out at room temperature, and the molar ratio of reagent–amine–carbonyl compound was 1:1:1.

^b Method 1: reaction was carried out in THF with 0.1 g Amberlyst 15.

^c Method 2: reaction was carried out under solvent-free conditions with 0.05 g Amberlyst 15.

^d Yield refers to pure isolated product.

^e Immediately.