Mild and Efficient Procedure for Michael Addition of N-Heterocycles to α,β-Unsaturated Compounds Using Anhydrous K₃PO₄ as Catalyst

Abstract

Imidazole, 1,2,4-triazole, indole, and benzotriazole undergo conjugate additions with α, β-unsaturated carbonyl compounds in the presence of anhydrous potassium phosphate at ambient temperature to afford the corresponding Michael adducts in excellent yields.

Keywords:

• Anhydrous potassium phosphate
• N-heterocycle
• imidazole
• Michael addition

ACKNOWLEDGMENTS

We thank the West Light Foundation of the Chinese Academy of Sciences (CAS, O729361401) for the financial support. Research was also supported by the CAS/State Administration of Foreign Experts Affairs (SAFEA) International Partnership Program for Creative Research Teams.

Notes

^a Isolated yield by silica-gel column chromatography.

^a Isolated yield by silica-gel column chromatography.