Efficient Acetylation of Alcohols, Phenols, and Amines Catalyzed by Melamine Trisulfonic Acid (MTSA)

Abstract

Melamine trisulfonic acid (MTSA) was easily prepared by the reaction of melamine with neat chlorosulfonic acid at room temperature. This reagent can be used as an efficient catalyst for the acetylation of alcohols, phenols, and amines with Ac₂O under mild and completely heterogeneous reaction conditions.

Keywords:

• Acetylation
• alcohols
• amines
• melamine
• melamine trisulfonic acid

ACKNOWLEDGMENT

We are thankful to the University of Guilan Research Council for the partial support of this work.

Notes

^a Products were identified spectroscopically.

^b Isolated yields.

^c Results obtained using recycled catalyst.

^d GC yields.