Facile Method for One-Step Synthesis of 2,4,5-Triarylimidazoles Under Catalyst-Free, Solvent-Free, and Microwave-Irradiation Conditions

Abstract

A green and efficient method for the synthesis of 2,4,5-triarylimidazoles by one-step condensation reaction of benzil, aromatic aldehyde, and ammonium acetate under catalyst-free, solvent-free, and microwave-irradiation conditions is reported. This method had many dramatic advantages, such as the short reaction time (3–5 min), good yields (80–99%), environmental friendliness, and convenient operation.

Keywords:

• Aromatic aldehyde
• benzil
• catalyst-free
• microwave irradiation
• solvent-free
• triarylimidazole

Notes

^a Microwave irradiated at 150 W.

^b All yields refer to isolated products.

^a Microwave irradiated at 150 W and 120 °C.

^b All yield refers to isolated products.