Synthesis, Reactions, and Antimicrobial Evaluation of Some Polycondensed Thienopyrimidine Derivatives

Abstract

Some novel indeno[2,1-b]thiophenes, indeno[1′,2′:4,5]thieno[2,3-d][1,2,3]triazines, indeno[1′,2′:4,5]thieno[2,3-d]pyrimidines, indeno[1′,2′:4,5]thieno[2,3-d][1,3]thiazolo[3,2-a]pyrimidines, and indeno[1′,2′:4,5]thieno[2,3-d][1,2,4]triazolo[4,3-a]pyrimidines 2–16 were prepared starting with 2-aminoindeno[2,1-b]thiophene-3-carboxylic acid amide ( 1 ). Furthermore, the antimicrobial evaluation of the prepared products showed that many of them revealed promising antimicrobial activity.

Keywords:

• Antimicrobial evaluation
• indeno[2,1-b]thiophenes
• indenothienopyrimidines
• thiazolothienopyrimidines
• thienotriazolopyrimidines

ACKNOWLEDGMENT

We are grateful to Dr. Hassan M. Awad, Department of Natural and Microbial Products, National Research Centre, for biological evaluation.

Notes

^a +++, highly sensitive (21–25 mm); ++, fairly sensitive (16–20 mm); +, slightly sensitive (15–10 mm); —, not sensitive (0–5 mm).