One-Pot, Three-Component Synthesis of 3-(5-Amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-ones

Abstract

A clean, efficient, one-pot, three-component method for the synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-one derivatives by condensation reaction of dimedone, 1H-pyrazol-5-amines, and isatins in aqueous media is reported.

Keywords:

• Dimedone
• isatin
• oxindole
• pyrazole

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of Shahid Beheshti University.

Notes

^a Dimedone (1 mmol), 1,3-diphenyl-1H-pyrazol-5-amine (1 mmol), isatin (1 mmol), and p-TSA (0.1 g).