Facile and Efficient One-Pot Synthesis of β-Carbolines

Abstract

Initial formation of tetrahydrocarboline 3 from tryptophan methyl ester 1 and aldehyde 2 by Pictet–Spengler reaction, followed by treatment with trichlorocyanuric acid, provides a facile and efficient route for a one-pot synthesis of β-carbolines with excellent yields.

Keywords:

• β-Carboline
• one pot
• synthesis

ACKNOWLEDGMENT

This work was supported by the National Natural Science Foundation of China (30470027 and 30225048).