Alternative Route to the Diisocyanate Building Block 1,4-Diisocyanato-4-methylpentane (DIMP)

Abstract

The synthesis of 1,4-diisocyanato-4-methylpentane was accomplished starting from isobutyronitrile in six steps with 53% overall yield. The two isocyanates were installed by a double Curtius rearrangement. The product reacts with alcohol in a regioselective manner.

Keywords:

• Curtius reaction
• dicarboxylic acid
• diisocyanate
• dinitrile

ACKNOWLEDGMENTS

The generous financial support from the Army Research Laboratory is gratefully acknowledged. Thanks to Ann M. Moorehead of the Technical Library for obtaining Ref. 1.

Notes

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