Efficient Procedure for Beckmann Rearrangement of Ketoximes Catalyzed by Sulfamic Acid/Zinc Chloride

Abstract

The Beckmann rearrangement of a variety of ketoximes to corresponding amides catalyzed by sulfamic acid and zinc chloride was carried out in good yields at refluxing temperature in acetonitrile.

Keywords:

• Amides
• Beckmann rearrangement
• cocatalyst
• ketoxime
• synthesis

ACKNOWLEDGMENT

The Natural Science Foundation of Hebei Province (B2006000969), China, supported the project.

Notes

^a Reaction conditions: acetophenone oxime (1 mmol), sulfamic acid (0.5 mmol), Lewis acids (0.2 mmol), solvent (3 mL), reflux, 2 h.

^a Acetophenone oxime: 1 mmol; acetonitrile: 3 mL; reflux.