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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 11
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Original Articles

Novel and Efficient Synthesis of Pyrimidine Derivatives

, , , &
Pages 1580-1587 | Received 18 Jan 2009, Published online: 06 May 2010
 

Abstract

A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.

ACKNOWLEDGMENTS

The authors gratefully acknowledge financial support of this project by the University Grants Commission, New Delhi, India. We also thank Dr. V. B. Gaikwad for his valuable cooperation.

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