N-Chlorosuccinimide/1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)–Mediated Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles

Abstract

A mixture of N-chlorosuccinimide and 1,8-diazabicyclo[5.4.0]undec-7-ene oxidatively cyclizes structurally diverse acyl hydrazone, thereby providing an efficient and convenient method for the synthesis of various 2,5-disubstituted 1,3,4-oxadiazoles. The salient features of this method are mild reaction conditions, short reaction time, excellent yields, and simple workup procedure.

Keywords:

• Acyl hydrazones
• N-chlorosuccinimide
• 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)
• 1,3,4-oxadiazoles
• oxidative cyclization

ACKNOWLEDGMENT

The author thanks the Indian Institute of Technology, Department of Chemistry, for providing the spectral data analysis.