Microwave-Induced Aza-Michael Reaction in Water: A Remarkably Simple Procedure

Abstract

Microwave-induced fast addition of several amines to conjugated carbonyl compounds has been carried out in water very efficiently in the absence of any catalyst.

Keywords:

• Amine
• aza-Michael
• enone
• green synthesis
• microwave irradiation

ACKNOWLEDGMENT

We gratefully acknowledge the funding support from the National Institutes of Health SCORE Program (Grant 2S06M008038-37).

Notes

Note. “Ref.” indicates the corresponding literature syntheses.

^a Isolated yield.