Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 11
267
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Diastereoselective Ruthenium-Catalyzed Michael Addition of Indoles to Hormone Steroids: An Efficient Route to New Indole Derivatives

, , &
Pages 1677-1684 | Received 29 Mar 2009, Published online: 06 May 2010
 

Abstract

Diastereoselective conjugate 1,4-addition of indoles to α,β-unsaturated carbonyl compounds (hormone steroids) using Ru(III) as catalyst is reported. It was found that RuCl3·nH2O catalyzes the Michael addition of indoles to hormone steroids, providing new 3-alkylated derivatives in good to excellent yields.

ACKNOWLEDGMENTS

The authors are grateful to the Research Council of Guilan University for partial support of this study.

Notes

a All products were characterized by 1H NMR, 13C NMR, and IR data.

b Isolated yield.

c Diastereomeric ratio was determined by 1H NMR spectroscopy.

a All products were characterized by 1H NMR, 13C NMR, and IR data.

b Isolated yield.

c Diastereomeric ratio was determined by 1H NMR spectroscopy.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.