Efficient Synthesis of Novel 2,4-[Diaryl-3-azabicyclo[3.3.1]nonan-9-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ²-1,3,4-thiadiazolines

Abstract

2,4-[Diaryl-3-azabicyclo[3.3.1]nonan-9-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ²-1,3,4-thiadiazoline derivatives (3a–h) have been synthesized by the cyclization of 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one thiosemicarbazones (2a–h) under acetylating condition. The synthesized compounds were characterized by analytical and spectral (infrared, ¹H NMR, and ¹³C NMR) studies.

Keywords:

• Acetic anhydride
• azabicyclo[3.3.1]nonan-9-ones
• cyclization
• thiadiazolines
• thiosemicarbazones

ACKNOWLEDGMENT

Authors are thankful to the NMR Research Centre, Indian Institute of Science, Bangalore for recording the NMR data.