Synthesis of New β-Acetamido Carbonyl Derivatives Using Cellulose Sulfuric Acid as an Efficient Catalyst

Abstract

New β-acetamido ketone derivatives are synthesized through a one-pot, four-component reaction of benzaldehyde, dimedone, acetyl chloride, and acetonitrile in the presence of cellulose sulfuric acid as an efficient reusable catalyst. The procedure offers advantages in terms of good yields, short reaction times, mild reaction conditions, and reusability of the catalyst.

Keywords:

• β-Acetamido ketones
• cellulose sulfuric acid
• Dakin–West reaction

ACKNOWLEDGMENT

The authors are thankful to Azzahra University Research Council for the partial financial support.

Notes

^a Yields refer to isolated products.

^a Yields refer to isolated products.

^a Yields refer to isolated products.

^a Yields refer to isolated products.