Simple and Efficient Procedure for the Synthesis of Novel 1,3-Diphenyl-2-azaphenalene Derivatives via One-Pot Multicomponent Reactions

Abstract

A new, one-pot multicomponent reaction of two molecules of aromatic aldehydes with 2,7-naphthalenediol and ammonium hydrogen phosphate is described as an efficient and direct procedure for the preparation of novel 1,3-diphenyl-2-azaphenalene derivatives in a mixture of EtOH-H₂O (3:1) under reflux conditions.

Keywords:

• Condensation
• 1,3-diphenyl-2-azaphenalene
• multicomponent
• naphthalenediol
• one-pot reaction

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

^a Isolated yields.

^b This reaction was carried out in EtOH-H₂O (3:1) as a solvent.

^a The product were characterized by IR, ¹H NMR, ¹³C NMR, and elemental analysis.

^b Isolated yields.