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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 13
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Original Articles

Convenient Synthesis of Pharmacologically Active Ortho-Substituted Biaryl Oxazolines via the Suzuki Reaction

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Pages 1907-1914 | Received 30 Mar 2009, Published online: 08 Jun 2010
 

Abstract

We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho-substituted biphenyl oxazolines from 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline and aryl boronic acids or aryl boronates. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous tetrahydrofuran. The scope and limitations of the reaction are discussed.

ACKNOWLEDGMENT

We are grateful to SVNIT, Surat, and the Indian Institute of Chemical Technology, Hyderabad, for supporting this work.

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