Zn[(L)proline]₂: An Efficient Catalyst for the Synthesis of Biologically Active Pyrano[2,3-d]pyrimidine Derivatives

Abstract

Biologically active pyrano[2,3-d]pyrimidine derivatives were efficiently synthesized in excellent yields by a three-component, one-pot condensation reaction of malononitrile, benzaldehydes, and barbituric acid using a catalytic amount of Zn[(L)proline].

Keywords:

• Barbituric acid
• pyrano[2,3-d]pyrimidine derivatives
• three-component one-pot reaction
• Zn[(L)proline]₂

Notes

^a Yields refer to isolated pure products.