Efficient, Ecofriendly, and Practical Process for the Synthesis of Quinoxalines Catalyzed by Amberlyst-15 in Aqueous Media

Abstract

Amberlyst-15/H₂O has been used as an efficient and environmentally friendly catalytic system for the synthesis of quinoxalines. The present methodology offers several advantages, such as excellent yields, short reaction time, and simple workup.

Keywords:

• Amberlyst-15
• 1,2-diamine
• 1,2-diketone
• quinoxaline
• water

ACKNOWLEDGMENT

We are grateful for financial support from the Research Foundation for the Doctoral Program of Tianjin Normal University.

Notes

^a All reactions were performed at 1 mmol scale using 24 mol% of amberlyst-15 in 15 mL of water.

^b All products were well characterized using ¹H NMR, ¹³C NMR, and elemental analysis.