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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 14
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Original Articles

Convenient Synthesis of 2-Aminothiophene Derivatives by Acceleration of Gewald Reaction Under Ultrasonic Aqueous Conditions

Mohammad M. Mojtahedi Chemistry and Chemical Engineering Research Center of Iran, Tehran, IranCorrespondence[email protected]
,
M. Saeed Abaee Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran
,
Peyman Mahmoodi School of Chemistry, University of Tehran, Tehran, Iran
&
Mehdi Adib School of Chemistry, University of Tehran, Tehran, Iran
Pages 2067-2074 | Received 18 Apr 2009, Published online: 17 Jun 2010
 
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Abstract

Under ultrasound irradiation and in the presence of H2O/Et2NH, ethyl cyanoacetate or malononitrile can combine with α-methylene carbonyl compounds and elemental sulfur to efficiently yield 2-aminothiophene derivatives within a few minutes. Products are easily obtained by simple filtration because of their spontaneous precipitation in the reaction mixtures.

ACKNOWLEDGMENT

Partial financial support by the Ministry of Science, Research, and Technology of Iran is greatly appreciated.

Notes

a Isolated yields.

a Ethylenediammonium diacetate.

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