Facile Heteropolyacid-Promoted Synthesis of Indeno[1,2-b]quinoline-9,11(6H,10H)-dione Derivatives

Abstract

An efficient synthesis of indeno[1,2-b]quinoline-9,11(6H,10H)-dione derivatives was reported via four-component coupling reaction of aldehydes, dimedone, 1,3-indandione, and amines in refluxing ethanol or three-component condensation of aldehydes, 1,3-indandione, and 5,5-dimethyl-3-arylamino-cyclohex-2-enone derivatives at 120 °C under solvent-free conditions in the presence of a catalytic amount of Preyssler-type heteropolyacid, H₁₄[NaP₅W₃₀O₁₁₀], as a green and reusable catalyst.

Keywords:

• Indeno[1,2-b]quinoline-9,11(6H,10H)-dione derivatives
• multicomponent reactions
• Preyssler-type heteropolyacid
• solvent-free synthesis

ACKNOWLEDGMENT

The authors are thankful to Azzahra Research Council for the partial financial support.

Notes

^a All reactions were run in 4-nitro benzaldehyde, dimedone, 1,3-indandione, and 4-methylaniline 1:1:1:1 (mmol) in refluxing ethanol.

^b Yields are related to isolated pure products.

^a Yields are related to isolated pure products.

^a Yields are related to isolated pure products.

^a Yields are related to isolated pure products.

^a Yields are related to isolated pure products.