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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 15
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Original Articles

p-Toluene Sulfonic Acid–Catalyzed, Solvent-Free Synthesis of Symmetrical Bisamides by Reaction Between Aldehydes and Amides

, , &
Pages 2209-2214 | Received 02 Jun 2009, Published online: 07 Jul 2010
 

Abstract

Reaction between aldehydes and amides catalyzed by p-toluene sulfonic acid in solvent-free conditions provided a simple and efficient one-pot route for the synthesis of symmetrical bisamide derivatives in excellent yields.

Notes

a Reaction conditions: 4-bromobenzaldehyde (1.0 mmol), acetamide (2.2 mmol), neat, 100 °C.

b Isolated yield.

a Isolated yield.

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