One-Pot, Multicomponent Sequential Synthesis of Benzothiazoloquinazolinones

Abstract

Benzothiazolo[2,3-b]quinazolin-1-ones have been synthesized by a multicomponent reaction of substituted 2-aminobenzothiazoles with cyclic β-diketone and aromatic aldehydes in the presence of absolute ethanol. The structures of the synthesized benzothiazoloquinazolinones have been characterized by elemental analysis and spectral studies.

Keywords:

• 2-Aminobenzothiazoles
• benzothiazoloquinazolinones
• CDK and GSK-3 inhibitors
• quinazolines
• thiazoloquinazolines

ACKNOWLEDGMENTS

The authors are thankful to the head of the Department of Chemistry, University of Rajasthan, Jaipur, India, for providing the necessary laboratory facilities as well as instrumentation facilities. We express our thanks to the University Grants Commission, New Delhi, for providing a meritorious student fellowship to P. K. S.