Improved Synthesis of L,L-Cycloisodityrosine Subunit of Antitumor Agents Deoxybouvardin and RA-VII

Abstract

A facile synthesis of the core cycloisodityrosine 14-membered ring system is detailed from commercially available L-tyrosine through a novel synthetic approach to aryl boronic acid 12 via intramolecular cyclization.

Keywords:

• Aryl boronate
• cycloisodityrosin
• deoxybouvardin
• palladium catalyst
• ring closure

ACKNOWLEDGMENTS

We are grateful to the Indian Association for Cultivation Sciences, Jadavpur, for analytical support, Pfizer Ltd., and SVNIT, Surat, India.