Solvent-Free Synthesis of α-Aminophosphonates from N-Heterocycles, Activated Acetylenes, and Diphenyl Phosphite

Abstract

A three-component, uncatalyzed synthesis of α-aminophosphonates via the reaction of isoquinoline or benzothiazole with activated acetylenes in moderate to good yields under solvent-free conditions is described.

Keywords:

• Activated acetylene
• α-aminophosphon
• benzothiazole
• diphenyl phosphite
• isoquinoline
• α-mercaptophosphonate