Benzimidazole-Derived ATP Analogues as Potential Glutamine Synthetase Inhibitors

Abstract

A series of mono- and dihydroxyalkyl- and -alkyloxybenzimidazoles and their phosphorylated derivatives have been prepared as adenosine triphoshate analogues for investigation as potential M. Tb. glutamine synthetase inhibitors.

Keywords:

• ATP analogues
• benzimidazole derivatives
• glutamine synthetase inhibitors
• phosphorylation

ACKNOWLEDGMENTS

We are grateful to the South African Department of Science and Technology (DST) Innovation Fund for a bursary (B.S.B.G.), the DST and Rhodes University for generous financial support, and Ms. Y. C. Lee for running additional NMR spectra.