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A series of chalcone derivatives containing thioglicolic acid (4a–j) was prepared by addition of thioglicolic acid to the chalcones (3a–j) in the presence of KOt-Bu under solvent-free conditions. The mechanistic pathway of the reaction can be explained by the Michael-type addition of thioglicolic acid to chalcone derivatives (3a–j).
The authors are indebted to the Technical Research Council of Turkey (Grant TUBITAK-106T103) for financial support of this work.
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