Abstract
Treatment of benzoin with an aldehyde and NH4OAc in polyethylene glycol (PEG-400) under reflux afforded a 5-substituted 2,3-diphenyl imidazole while the same reaction along with an additional aniline produced 5-substituted 1-aryl 2,3-diphenyl imidazole. No any catalyst or solvent was required to carry out this conversion, and the imidazoles were formed in excellent yields.
ACKNOWLEDGMENTS
The authors thank the Council of Scientific and Industrial Research and the University Grants Commission, New Delhi, for financial assistance.
Notes
a The structures of the products were settled from their spectral (IR, 1H NMR, and MS) and analytical data.
a The structures of the products were settled from their spectral (IR, 1H NMR, and MS) and analytical data.
Part 185 in the series “Studies on Novel Synthetic Methodologies.”