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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 18
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Original Articles

Efficient Synthesis of 5-Substituted 2,3-Diphenyl and 5-Substituted 1-Aryl-2,3-diphenyl Imidazoles Using Polyethylene Glycol

, &
Pages 2667-2675 | Received 29 May 2009, Published online: 09 Aug 2010
 

Abstract

Treatment of benzoin with an aldehyde and NH4OAc in polyethylene glycol (PEG-400) under reflux afforded a 5-substituted 2,3-diphenyl imidazole while the same reaction along with an additional aniline produced 5-substituted 1-aryl 2,3-diphenyl imidazole. No any catalyst or solvent was required to carry out this conversion, and the imidazoles were formed in excellent yields.

ACKNOWLEDGMENTS

The authors thank the Council of Scientific and Industrial Research and the University Grants Commission, New Delhi, for financial assistance.

Notes

a The structures of the products were settled from their spectral (IR, 1H NMR, and MS) and analytical data.

a The structures of the products were settled from their spectral (IR, 1H NMR, and MS) and analytical data.

Part 185 in the series “Studies on Novel Synthetic Methodologies.”

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