Aza-Michael Addition of Amines to α,β-Unsaturated Compounds Using Molecular Iodine as Catalyst

Abstract

Aza-Michael adducts are obtained in very good yields by the conjugate addition of aliphatic amines to α,β-unsaturated compounds using molecular iodine as catalyst in dichloromethane at room temperature. Aromatic amines were found to be reactive under reflux in toluene.

Keywords:

• Amine
• β-amino carbonyl compound
• aza-Michael addition
• iodine
• α,β-unsaturated compounds

ACKNOWLEDGMENTS

The authors are thankful to the Council of Scientific and Industrial Research, New Delhi, India, for Research Project Grant No. 01(2067)/06/EMR-II to R. B. and to Central Instrument Facility, Indian Institute of Technology, Guwahati, for their cooperation in sample analysis.

Notes

^a All the products were characterized by ¹H NMR, IR, and mass spectrometry.

^b Isolated yields.

^a All the products were characterized by ¹HNMR, IR, and mass spectrometry.

^b Isolated yields.