Efficient One-Pot Synthesis of Benzimidazoles Under Solvent-Free Conditions

Abstract

A green, efficient method for the synthesis of various 2-aryl-benzimidazoles in the presence of hypervalent iodine as the oxidant at room temperature under solvent-free conditions is reported. The salient features of this method include mild conditions, short reaction times (3–5 min), excellent yields, and simple procedure.

Keywords:

• Benzimidazoles
• green chemistry
• iodobenzene diacetate (IBD)
• oxidations

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Zhejiang Province (Y4080126), the Science and Technology Research Program of Zhejiang Province (2008C12084), as well as the Natural Science Foundation of Zhejiang University of Technology (116004029) for financial support.

Notes

^a Isolated yield.

^a Isolated yield.