Highly Selective Claisen–Schmidt Condensation Catalyzed by Silica Chloride Under Solvent-Free Reaction Conditions

Abstract

Silica chloride serves as a useful catalyst in the cross-aldol condensation, leading to the synthesis of a wide variety of bisarylidene cycloalkanones and chalcones. The catalyst showed high selectivity; self-condensation of ketones was not observed.

Keywords:

• Aldol reaction
• arylidene cycloalkanone
• Claisen–Schmidt
• condensation
• silica chloride

ACKNOWLEDGMENTS

H. Hazarkhani is thankful to the director of NCL, Pune, for allowing him to work as a guest worker. We are grateful to Dr. G. Pandey, head of the Organic Division, for his support and encouragement.

Notes

^a Products were characterized by ¹H NMR, ¹³C NMR, and mass spectroscopy and also by comparison with authentic samples.

^b Isolated yield.

^a Products were characterized by ¹H NMR, ¹³C NMR, and mass spectroscopic data and also by comparison with authentic samples.

^b Isolated yield.