Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction

M. B. Madhusudana Reddy Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, India

V. P. Jayashankara Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, India

M. A. Pasha Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, IndiaCorrespondence[email protected]

Abstract

A facile and convenient protocol is developed for the fast (5–20 min) and high-yielding (85–95%) synthesis of fused pyranopyrazoles from ethyl acetoacetate, hydrazine hydrate, an aldehyde, and malononitrile in the presence of nontoxic, simple, and readily available organocatalyst glycine in aqueous medium at 25 °C.

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Notes

^aAll the products were known and characterized by comparison with the authentic samples.

^bYield refers to isolated product.

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Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction

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Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction

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