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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 19
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Original Articles

Sodium Dihydrogen Phosphate as an Efficient Catalyst for One-Pot, Three-Component Synthesis of α-Aminophosphonates Under Solvent-Free Conditions at Room Temperature

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Pages 2948-2953 | Received 20 Aug 2009, Published online: 25 Aug 2010
 

Abstract

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-aminophosphonates from a condensation reaction of trimethyl phosphite, aldehydes, and amines in the presence of sodium dihydrogen phosphate under solvent-free conditions. Thus, α-aminophosphonates were synthesized relatively quickly in good yields at room temperature.

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Islamic Azad University of Firoozabad.

Notes

a All reactions are carried out under same conditions as Table 1, entry a.

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