Abstract
A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of this new method include excellent yields under both microwave-assisted or thermal conditions (it is tolerant of a variety of substituents on the phenyl ring) and simple product isolation without the need for chromatographic purification.
ACKNOWLEDGMENTS
We thank the Welsh School of Pharmacy, Cardiff University, for PhD studentship funding (ADW/AAW), and the BBSRC (BB/D524140) for research grant funding (MCB/MCD).
Notes
a All yields refer to isolated products that were characterized by mp, 1H NMR, 13C NMR, mass spectrometry, and microanalysis (% C, H, N).
b Compound identity established by comparison of 1H NMR data.