Rapid and Efficient Synthesis of (R)-Aryloxypropionic Acid Esters Under Microwave Irradiation

Abstract

A series of (R)-(+)-ethyl aryloxypropionates (4a–4p) have been synthesized by the reaction of substituted phenols with ethyl (S)-(−)-tosyloxy lactate under the conditions of microwave irradiation and without solvents. The reaction conditions have been optimized. A good method for the preparation of (R)-(+)-ethyl aryloxypropionate was developed, with good yields, high enantiomer excess, short reaction times, easy workup, and simple procedure.

Keywords:

• (R)-(+)-Ethyl aryloxypropionates
• microwave irradiation
• pesticides
• solvent-free organic synthesis

ACKNOWLEDGMENT

This work was financially supported by the Polish State Committee for Scientific Research Grant No. N N209 119937 and Warsaw Technical University.