Practical Synthesis of FEt-penta-cyclofenil and Its Derivatives for Potential PET Imaging

Hua Zhu Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; Graduate School of the Chinese Academy of Sciences, Beijing, China

Liliang Huang Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; Graduate School of the Chinese Academy of Sciences, Beijing, China

Xiaoping Xu Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; Graduate School of the Chinese Academy of Sciences, Beijing, China

Yu-Mei Shen Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; Shanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaCorrespondence[email protected]

Abstract

Generally, FEt-penta-cyclofenil and its derivatives have greater relative binding affinity to estradiol receptors than estradiol. (4-Fluoroethoxyphenyl)–(4′-hydroxyphenyl) methylenecyclopentane and its derivatives were synthesized for potential radioactive image agents, and their structures were characterized by ultraviolet, infrared, ¹H NMR, ¹⁹F NMR, and high-resolution mass spectrometry.

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ACKNOWLEDGMENT

This project was supported by the Hundred Talent Program of the Chinese Academy of Sciences (No. 26200601).

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Practical Synthesis of FEt-penta-cyclofenil and Its Derivatives for Potential PET Imaging

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Practical Synthesis of FEt-penta-cyclofenil and Its Derivatives for Potential PET Imaging

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