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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 22
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Original Articles

Efficient and High-Yielding Protocol for the Synthesis of Nitriles from Aldehydes

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Pages 3384-3389 | Received 04 Aug 2009, Published online: 15 Oct 2010
 

Abstract

An operationally simple and high-yielding procedure has been developed for the conversion of araldehydes into the corresponding nitriles using p-toluenesulfonic acid (p-TSA) (a mild catalyst) under microwave irradiation. The products are characterized by infrared spectral analysis and by comparison of the melting and boiling points with the reported values.

Notes

a All the products are known and were characterized by IR spectral analysis and comparison of their melting and boiling points with the authentic samples prepared by the reported method [Ref. 15].

b Isolated yield.

a Isolated yield (column chromatography).

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