Solvent-Free, Cross-Aldol Condensation Reaction Using Silica-Supported, Phosphorus-Containing Reagents Leading to α,α′-Bis(arylidene)cycloalkanones

Abstract

This article describes an efficient, simple, and clean method for the synthesis of α,α′-bis(arylidene, furylidene and cinnamylidene)cycloalkanones under solvent-free conditions. The cross-aldol condensation of cycloalkanones with aldehydes in the presence of silica-supported phosphorus pentoxide (P₂O₅/SiO₂) or silicaphosphinoxide (silphox, [POCl_3-n(SiO₂)_n]) as heterogeneous reagents produces the title compounds in good to excellent yields.

Keywords:

• α,α′-Bis(arylidene)cycloalkanone
• cross-aldol condensation
• green chemistry
• P₂O₅/SiO₂
• silphox
• solvent-free

ACKNOWLEDGMENTS

We appreciate the Persian Gulf University and Payame Noor University (PNU) Research Councils for the financial support of this work.

Notes

^a Isolated yield.

^a Isolated yield.

^a Isolated yield.