One-Pot, Three-Component Coupling Reaction: Catalyst-Free Green Synthesis of Novel N-Heteroaryl α-Naphthylglycines

Abstract

A series of novel N-heteroaryl α-arylglycines containing naphthol rings has been prepared by one-pot, three-component condensation reaction of glyoxalic acid, heteroaryl amines and naphthols in water at ambient temperature and under reflux conditions in moderate to high yields. The promising advantages such as removal of organic solvent, no need to catalyst, simplicity of the reaction procedure and easy product separation will be discussed in this article.

Keywords:

• Glyoxalic acid
• heteroaryl amines
• naphthols
• α-naphthylglycines

ACKNOWLEDGMENT

The authors wish to thank the Research Council of the Payame Noor University of Qazvin for financial support.