A Highly Efficient Synthesis of Sulphonamide Derivatives in the Presence of N-Methyl-2-pyrrolidone

Abstract

The sulphonamide derivatives are synthesized by two component condensation of alkyl bromide and sodium arylsulphonamide using N-methyl-2-pyrrolidone (NMP) as a reaction medium. This method results in high yields without the formation of unwanted side products, and expanding substrate scopes.

Keywords:

• Amides
• NMP
• nucleophiles
• solvent effects
• synthesis

ACKNOWLEDGMENT

This work was supported by National Natural Science Foundation (20574016).

Notes

^a Yields refer to pure isolated products.