Mild and Efficient Synthesis of Benzimidazole Using Lead Peroxide Under Solvent-Free Conditions

Abstract

Benzimidazole derivatives have been synthesized using a catalytic amount of lead peroxide (PbO₂) at room temperature with excellent yields. The remarkable selectivities under mild, neutral and solvent-free conditions and use of a commercially available, inexpensive catalyst are attractive features of this method.

Keywords:

• Benzimidazoles
• lead peroxide
• solvent free

ACKNOWLEDGMENT

The authors acknowledge the partial support of this work by Prof. B. P. Bandgar, Vice Chancellor, University of Solapur, India.

Notes

^a The substrate was treated with benzaldehyde (2 mmol) using 0.1 mmol of PbO₂ in solvent-free conditions and at room temperature.

^b All products were identified by their IR and ¹H NMR spectra.

^c Isolated yields.