Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 41, 2010 - Issue 1

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Original Articles

Lactam Coupling as a Versatile Route to Indoprofen Analogs

Keith D. Barnes Medicinal Chemistry Department, AMRI, Albany, New York, USA

Ping Chen Medicinal Chemistry Department, AMRI, Albany, New York, USA

Yingyan Chang Medicinal Chemistry Department, AMRI, Albany, New York, USA

Robert M. Lewis Medicinal Chemistry Department, AMRI, Albany, New York, USA

Christopher M. Manley Medicinal Chemistry Department, AMRI, Albany, New York, USA

Nicholas J. Mayhew Medicinal Chemistry Department, AMRI, Albany, New York, USA

Stephen H. Steffke Medicinal Chemistry Department, AMRI, Albany, New York, USA

Guixing Wang Medicinal Chemistry Department, AMRI, Albany, New York, USA

Yi Wang Medicinal Chemistry Department, AMRI, Albany, New York, USA

Yuh-Lin A. Yang Medicinal Chemistry Department, AMRI, Albany, New York, USA

John W. Lippert III Medicinal Chemistry Department, AMRI, Albany, New York, USACorrespondence[email protected]

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Abstract

A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were readily prepared.

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ACKNOWLEDGMENTS

The authors acknowledge Drs. Jill Heemskerk (National Institute of Neurological Disorders and Stroke), John M. McCall (PharMac LLC), Sabina Robinson (Science Applications International Corporation), Amelie Gubitz (National Institute of Neurological Disorders and Stroke), and James A. Romano Jr. (Science Applications International Corporation) for their advice, direction, and support on this project. This project has been funded in whole or in part with federal funds from the National Institute of Neurological Disorders and Stroke, National Institute of Health, under Contract No. N01-NS-3-2356.

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Lactam Coupling as a Versatile Route to Indoprofen Analogs

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Lactam Coupling as a Versatile Route to Indoprofen Analogs

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ACKNOWLEDGMENTS

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