Synthesis and Characterization of Potential Impurities of Carvedilol, an Antihypertensive Drug

Abstract

Carvedilol (Coreg) is a nonselective β-adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities.

Keywords:

• Carvedilol
• impurities
• spectral characterization
• synthesis

ACKNOWLEDGMENTS

The authors are grateful to colleagues in the Analytical Research and Development department and the management of Srini Pharmaceuticals Ltd. for providing the necessary support.