Silica-Gel–Catalyzed Efficient Synthesis of Quinoxaline Derivatives Under Solvent-Free Conditions

Abstract

Quinoxaline derivatives have been prepared in good to excellent yields using silica gel as catalyst from various 1,2-diketones and 1,2-diamines under solvent-free conditions for the first time. The advantages of this method are short reaction time, reaction simplicity, convenient workup procedure, and purification of compounds by a nonchromatographic method.

Keywords:

• 1,2-Diamines
• 1,2-diketones
• quinoxaline
• silica gel

ACKNOWLEDGMENTS

G. C. N. and and S. S. are thankful to the Council of Scientific and Industrial Research, New Delhi, for financial assistance in the form of Senior research fellowships. Ram Kumar is thankful to M. D. LLC, USA.