Nanocrystalline Copper(II) Oxide–Catalyzed One-Pot Synthesis of Imidazo[1,2-a]quinoline and Quinolino[1,2-a]quinazoline Derivatives via a Three-Component Condensation

Abstract

A simple, efficient, and practical procedure for the synthesis of imidazo[1,2-a]quinoline and quinolino[1,2-a]quinazoline derivatives using CuO nanoparticles as a novel catalyst in excellent yields is described. The catalyst can be recovered conveniently and reused at least four times without any loss of activity.

Keywords:

• CuO nanoparticles
• imidazo[1,2-a]quinoline
• quinolino[1,2-a]quinoline

ACKNOWLEDGMENT

The authors are thankful to the Nuclear Science and Technology Research Institute for the partial financial support.

Notes

^a Reaction conditions: benzaldehyde (1 mmol), malononitrile (1 mmol), and enaminone 1a (1 mmol), x mmol% catalyst; water; 50 °C.