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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 11
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Original Articles

Palladium-Catalyzed N-Arylation of 3-Functionalized 2-Amino-4,5-dimethylpyrroles

, , &
Pages 1672-1681 | Received 08 Dec 2009, Published online: 20 Apr 2011
 

Abstract

A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladium-catalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

ACKNOWLEDGMENTS

We thank our department and the Pamplin College of Arts and Sciences for funding of this research.

Notes

a Isolated yield of pure product after column chromatography.

b Based on TLC comparison to an authentic sample.

a Isolated yield of pure product after column chromatography.

b Based on 1H NMR of the partially purified product.

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