Abstract
A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladium-catalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.
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ACKNOWLEDGMENTS
We thank our department and the Pamplin College of Arts and Sciences for funding of this research.
Notes
a Isolated yield of pure product after column chromatography.
b Based on TLC comparison to an authentic sample.
a Isolated yield of pure product after column chromatography.
b Based on 1H NMR of the partially purified product.