Abstract
The reaction of various o-phenylenediamines and substituted benzaldehydes was carried out in 1 M glucose solution as reaction medium and catalyst under one-pot oxidant-free conditions. The desired products were obtained at 60 °C with good to excellent yields, and the reaction was performed chemoselectively without formation of 1,2-disubstituted benzimidazoles. No need for any extra oxidant, simple workup, and use of carbohydrates as fully green promoters are some advantages of the present work.
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ACKNOWLEDGMENT
The authors gratefully acknowledge the Research Council of K. N. Toosi University of Technology for partial financial support of this work.
Notes
a Reaction conditions: o-phenylenediamine (1 mmol), benzaldehyde (1 mmol), and different volumes of aqueous 1 M glucose solution.
b Isolated yield.
a Isolated yield.