Iodine-Catalyzed, Efficient, One-Pot Protocol for the Conversion of Araldehydes into 5-Aryl-1H-tetrazoles

Abstract

An easy access to various 5-aryl-1H-tetrazoles by a one-pot direct conversion of aldehydes to tetrazoles without the isolation of the intermediate nitriles using commercially available iodine as a catalyst is described. The protocol offers advantages in terms of good yields, mild reaction conditions, short reaction times, and use of readily available environmentally compatible catalyst.

Keywords:

• Ammonia
• araldehydes
• 5-aryl-1H-tetrazoles
• iodine
• sodium azide

ACKNOWLEDGMENT

One of the authors, M. B. Madhusudana Reddy, thanks Mr. Narayana Reddy, teacher, Government Primary School, Hemavathi, Madakasira, A. P., India, for constant encouragement.

Notes

^a All reactions were performed using an aldehyde (5 mmol), sodium azide (6 mmol), and I₂ (2equivalents).

^b Isolated yield.

^c All the products are known, and physical properties agree with the literature values.