Studies Towards the Synthesis of ATP Analogs as Potential Glutamine Synthetase Inhibitors

Abstract

In research directed at the development of adenine triphosphate (ATP) analogs as potential glutamine synthetase (GS) inhibitors, adenine and allopurinol derivatives have been synthesized either as novel ATP analogs or as scaffolds for the construction of such analogs.

Keywords:

• Adenine
• allopurinol
• Baylis–Hillman products
• glutamine synthetase inhibitors

ACKNOWLEDGMENTS

We are grateful to the South African Department of Science and Technology (DST) Innovation Fund for a bursary (S. S.) and the Department of Science and Technology and Rhodes University for generous financial support.