Transformation of Amines to Oximes Using Heterogeneous Nanocrystalline Titanium(IV) Oxide as a Green Catalyst

Abstract

The oxidation of amines into corresponding oximes has been described using heterogeneous nanocrystalline titanium(IV) oxide as catalyst and H₂O₂ as oxidizing agent in quantitative yields. Both aromatics and aliphatic amines undergo oxidation. Besides this, nanocrystalline TiO₂ was recovered and used for further reactions. Hence our present protocol is economical and clean and uses green reagent, solvent, and catalyst.

Graphical Abstract

Keywords:

• Green chemistry
• nanoparticles
• oxidation
• oxime

Notes

^aReaction conditions: benylamine (1 mmol), hydrogen peroxide (4 mmol), and 10 mol% catalyst; MeOH; temperature 60 °C.

^aReaction conditions: benzylamine (1 mmol), hydrogen peroxide (4 mmol), and 10 mol% nanoTiO₂ (50 ± 2) nm; solvent; temperature 60 °C.

^bIsolated yields.

^aReaction conditions: benzylamine (1 mmol), hydrogen peroxide (4 mmol), and 10 mol% nanoTiO₂ (50 ± 2) nm; MeOH; temperature 60 °C.

^bIsolated yields.

^aReaction conditions: benzylamine (1 mmol), hydrogen peroxide (4 mmol), and 10 mol% nanoTiO₂ (50 ± 2) nm; MeOH; temperature 60 °C.

^bIsolated yields.